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Maiani, E., Milletti, G., Nazio, F., Holdgaard, S.G., Bartkova, J., Rizza, S., Cianfanelli, V., Lorente, M., Simoneschi, D., Di Marco, M., D'Acunzo, P., Di Leo, L., Rasmussen, R., Montagna, C., Raciti, M., De Stefanis, C., Gabicagogeascoa, E., Rona, G., Salvador, N., Pupo, E., Merchut-Maya, J.M., Daniel, C.J., Carinci, M., Cesarini, V., O'Sullivan, A., Jeong, Y.T., Bordi, M., Russo, F., Campello, S., Gallo, A., Filomeni, G., Lanzetti, L., Sears, R.C., Hamerlik, P., Bartolazzi, A., Hynds, RE., Pearce, D.R., Swanton, C., Pagano, M., Velasco, G., Papaleo, E., De Zio, D., Maya-Mendoza, A., Locatelli, F., Bartek, J. and Cecconi, F.
AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity.
Nature (2021)

Frauenfelder, C., Hall, A., Walsh, B., Ross, A., Broughton, E., Hynds, R.E., Nandi, R., O’Callaghan, C., Butler, C.R.
Use of simulation to visualise healthcare worker exposure to aerosol in the operating room.
Simulation in Healthcare (2021).

Lee, D.D.H., Cardinale, D., Nigro, E., Butler, C.R., Rutman, A., Fassad, M.R., Hirst, R.A., Moulding, D., Agrotis, A., Forsythe, E., Peckham, D., Robson, E., Smith, C.M., Somavarapu, S., Beales, P.L., Hart, S.L., Janes, S.M., Mitchison, H.M., Ketteler, R., Hynds, R.E. and O'Callaghan, C.
Higher throughput screening for rare respiratory diseases: readthrough therapy in primary ciliary dyskinesia.
European Respiratory Journal (2021)

Guillotin, D., Taylor, A.R., Platé, M., Mercer, P.F., Edwards, L.M., Haggart, R., Miele, G., McAnulty, R.J., Maher, T.M., Hynds, R.E., Jamal-Hanjani, M., Marshall, R.P., Fisher, A.J., Blanchard, A.D. and Chambers, R.C.
Transcriptome analysis of IPF fibroblastic foci identifies key pathways involved in fibrogenesis.
Thorax (2021)

Pennycuick, A., Teixeira, V.H., AbdulJabbar, K., Ahmed Raza, S.E., Lund, T., Akarca, A., Rosenthal, R., Kalinke, L., Chadrasekharan, D.P., Pipinikas, C.P., Lee-Six, H., Hynds, R.E., Gowers, K.H.C., Henry, J.Y., Millar, F.R., Hagos, Y.B., Denais, C., Falzon, M., Moore, D.A., Antoniou, S., Durrenberger, P.F., Furness, A., Carroll, B., Marceaux, C., Asselin-Labat, M., Larson, W., Betts, C., Coussens, L.M., Thakrar, R., George, P.J., Swanton, C., Thirlwell, C., Campbell, P.J., Marafioti, T., Yuan, Y., Quezada, S.A., McGranahan, N. and Janes, S.M.
Immune surveillance in clinical regression of pre-invasive squamous cell lung cancer.
Cancer Discovery (2020)

Maughan, E.F., Nigro, E., Pennycuick, A., Gowers, K.H.C., Denais, C., Gómez-López, S., Lazarus, K.A., Butler, C.R., Lee, D.D.H., Orr, J.C., Teixeira, V.H., Hartley, B.E., Hewitt, R.J., Al Yaghchi, C., Sandhu, G.S., Birchall, M.A., O'Callaghan, C., Smith, C.M., De Coppi, P., Hynds, R.E. and Janes, S.M.
Cell-intrinsic differences between human airway epithelial cells from children and adults.
bioRxiv (2020)

Hamilton, N.J.I., Lee, D.D.H., Gowers, K.H.C., Butler, C.R., Maughan, E.F., Jevans, B., Orr, J.C., McCann, C.J., Burns, A.J., MacNeil, S., Birchall, M.A., O'Callaghan, C., Hynds, R.E. and Janes, S.M.
Bioengineered airway epithelial grafts with mucociliary function based on collagen IV- and laminin-containing extracellular matrix scaffolds.
European Respiratory Journal (2020)

Yoshida, K., Gowers, K.H.C., Lee-Six, H., Chandrasekharan, D.P., Coorens, T., Maughan, E.F., Beal, K., Menzies, A., Millar, F.R., Anderson, A., Clarke, S.E., Pennycuick, A., Thakrar, R.M., Butler, C.R., Kakiuchi, N., Hirano, T., Hynds, R.E., Stratton, M.R., Martincorena, I., Janes, S.M., and Campbell, P.J.
Tobacco smoking and somatic mutations in human bronchial epithelium.
Nature (2020)

Lee, D.D.H., Petris, A., Hynds, R.E. and O'Callaghan, C.
Ciliated epithelial cell differentiation at air-liquid interface using commercially available culture media.
Methods in Molecular Biology (2019)

Jones, G.G., del Río, I.B., Sari, S., Sekerim, A., Young, L.C., Hartig, N., Zubiaur, I.A., El-Bahrawy, M.A., Hynds, R.E., Lei, W., Molina-Arcas, M., Downward, J. and Rodriguez-Viciana, P.
SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers.
Nature Communications (2019)

Teixeira, V.H., Pipinikas, C., Pennycuick, A., Lee-Six, H., Chandrasekharan, D., Beane, J., Morris, T., Karpathakis, A., Feber, A., Breeze, C., Ntolios, P., Hynds, R.E., Falzon, M., Capitanio, A., Carroll, B., Durrenberger, P., Hardavella, G., Brown, J., Lynch, A., Farmery, J., Paul, D., Chambers, R.C., McGranahan, N., Navani, N., Thakrar, R., Swanton, C., Beck, S., George, P.J., Spira, A. Campbell, P., Thirlwell, C. and Janes, S.M.
Deciphering the genomic, epigenomic and transcriptomic landscapes of pre-invasive lung cancer lesions.
Nature Medicine (2019)

Hamilton, N., Hynds, R.E., Gowers, K.H.C., Tait, A., Butler, C.R., Hopper, C., Burns, A.J., Birchall, M.A., Lowdell, M. and Janes, S.M.
Using a 3D collagen matrix to deliver respiratory progenitor cells to decellularized trachea in vivo.
Tissue Engineering Part C (2019)

Crowley, C., Butler, C.R., Camilli, C., Hynds, R.E., Kolluri, K., Janes, S.M., De Coppi, P. and Urbani, L.
Non-invasive longitudinal bioluminescence imaging of human mesoangioblasts in bioengineered esophagi.
Tissue Engineering Part C (2019)

Ogunlade, O., Ho, J.O.Y., Kalber, T.L., Hynds, R.E., Zhang, E., Janes, S.M., Birchall, M.A., Butler, C.R. and Beard, P.
Monitoring neovascularization and integration of decellularized human scaffolds using photoacoustic imaging.
Photoacoustics (2019)

Woodcock, H.V., Eley, J.D., Guillotin, D., Platé, M., Nanthakumar, C.B., Martufi, M., Peace, S., Joberty, G., Poeckel, D., Good, R.B., Taylor, A.R., Zinn, N., Redding, M., Forty, E.J., Hynds, R.E., Swanton, C., Karsdal, M., Maher, T.M., Bergamini, G., Marshall, R.P., Blanchard, A.D., Mercer, P.F., Chambers, R.C.
The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis.
Nature Communications (2019)

Hynds, R.E., Gowers, K.H., Nigro, E., Butler, C.R., Bonfanti, P., Giangreco, A., Prêle, C.M. and Janes, S.M.
Cross-talk between human airway epithelial cells and 3T3-J2 feeder cells involves partial activation of human MET by murine HGF.
PLOS ONE (2018)

Hynds, R.E., Ben Aissa, A., Gowers, K.H.C., Watkins, T.B.K., Bosshard-Carter, L., Rowan, A.J., Veeriah, S., Wilson, G.A., Quezada, S.A., Swanton, C., TRACERx Consortium, Janes S.M.
Expansion of airway basal epithelial cells from primary human non-small cell lung cancer tumors.
International Journal of Cancer (2018)

Gowers, K.H., Hynds, R.E., Thakrar, R.M., Carroll, B., Birchall, M.A. and Janes, S.M.
Optimized isolation and expansion of human airway epithelial basal cells from endobronchial biopsy samples.
Journal of Tissue Engineering and Regenerative Medicine (2017)

Maughan, E.F., Butler, C.R., Crowley, C., Teoh, G.Z., Den Hondt, M., Hamilton, N.J., Hynds, R.E., Lange, P., Ansari, T., Urbani, L., Janes, S.M., De Coppi, P., Birchall, M.A. and Elliott, M.J.
A comparison of tracheal scaffold strategies for pediatric transplantation in a rabbit model.
The Laryngoscope (2017)

Elliott, M., Varanou-Jenkins, A., Partington, L., Carvalho, C., Samuel, E., Crowley, C., Lange, P., Hamilton, N., Hynds, R.E., Ansari, T., Sibbons, P., Fierens, A., McLaren, C., Roebuck, D., Wallis, C., Muthialu, N., Hewitt, R., Crabbe, D., Janes, S.M., De Coppi, P., Lowdell, M.W., Birchall, M.A.
Tracheal replacement therapy with a stem cell-seeded graft: lessons from compassionate use application of a GMP-compliant tissue-engineered medicine.
Stem Cells Translational Medicine (2017)

Butler, C.R., Hynds, R.E., Crowley, C., Gowers, K.H.C., Partington, L., N.J. Hamilton, Carvalho, C., Plate, M., Samuel, E.R., Burns, A.J., Urbani, L., Birchall, M.A., Lowdell, M.W., De Coppi, P. and Janes, S.M.
Vacuum-assisted decellularization: an accelerated protocol to generate tissue-engineered human tracheal scaffolds.
Biomaterials (2017)

Hynds, R.E., Butler, C.R., Janes, S.M. and Giangreco, A.
Expansion of Human Airway Basal Stem Cells and Their Differentiation as 3D Tracheospheres.
Methods in Molecular Biology (2016)

Butler, C.R.*, Hynds, R.E.*, Gowers, K.H.C., Lee, D.D., Brown, J., Crowley, C., Teixeira, V.H., Smith, C., Urbani, L., Hamilton, N.J., Thakrar, R.M., Booth, H.L., Birchall, M.A., De Coppi, P., Giangreco, A., O'Callaghan, C. and Janes, S.M.
Rapid Expansion of Human Epithelial Stem Cells Suitable for Airway Tissue Engineering.
American Journal of Respiratory and Critical Care Medicine (2016)

Crowley, C., Klanrit, P., Butler, C.R. Varanou, A., Plate, M., Hynds, R.E., Chambers, R., Seifalian, A., Birchall, M.A. and Janes, S.M.
Surface modification of a POSS-nanocomposite material to enhance cellular integration of a synthetic bioscaffold.
Biomaterials (2016)

Lee, J.L. and Hynds, R.E.
Divergent cellular pathways of hippocampal memory consolidation and reconsolidation.
Hippocampus (2013)

Orr, J.C. and Hynds, R.E.
Stem Cell-Derived Respiratory Epithelial Cell Cultures as Human Disease Models.
American Journal of Respiratory Cell and Molecular Biology (2021)

Hynds, R.E., Frese, K., Pearce, D., Grönroos, E., Dive, C. and Swanton, C.
Progress towards non-small cell lung cancer models that represent clinical evolutionary trajectories.
Open Biology (2021)

Hynds, R.E., Bonfanti, P. and Janes, S.M.
Reconstructing the human epithelial stem cell niche in vitro: 3T3 cells, organoids and beyond.
EMBO Molecular Medicine (2018)

Maughan, E.F., Hynds, R.E., Proctor, T.J., Janes, S.M., Elliott, M., Birchall, M.A., Lowdell, M.W. and De Coppi, P.
Autologous cell seeding in tracheal tissue engineering.
Current Stem Cell Reports (2017)

Maughan, E., Lesage, F. Butler, C.R., Hynds, R.E., Hewitt, R., Janes, S.M., Deprest, J.A. and De Coppi, P.
Airway tissue engineering for congenital laryngotracheal disease.
Seminars in Pediatric Surgery (2016)

Vallath, S., Hynds, R.E., Succony, L., Janes, S.M. and Giangreco, A.
Targeting EGFR signalling in chronic lung disease: therapeutic challenges and opportunities.
European Respiratory Journal (2014)

Hynds, R.E. and Giangreco, A.
Concise review: the relevance of human stem cell-derived organoid models for epithelial translational medicine.
Stem Cells (2013)

AbdulJabbar, K., Raza, S.E.A., Rosenthal, R., Jamal-Hanjani, M., Veeriah, S., Akarca, A., Lund, T., Moore, D.A., Salgado, R., Al Bakir, M., Zapata, L., Hiley, C.T., Officer, L., Sereno, M., Smith, C.R., Loi, S., Hackshaw, A., Marafioti, T., Quezada, S.A., McGranahan, N., Le Quesne, J., TRACERx Consortium, Swanton, C., Yuan, Y.
Geospatial immune variability illuminates differential evolution of lung adenocarcinoma.
Nature Medicine (2020)

Ghorani, E., Reading, J.L., Henry, J.Y., de Massy, M.R., Rosenthal, R., Turati, V., Joshi, K., Furness, A.J.S., Ben Aissa, A., Saini, S.K., Ramskov, S., Georgiou, A., Werner Sunderland, M., Wong, Y.N.S., De Mucha, M.V., Day, W., Galvez-Cancino, F., Becker, P.D., Uddin, I., Oakes, T., Ismail, M., Ronel, T., Woolston, A., Jamal-Hanjani, M., Veeriah, S., Birkbak, N.J., Wilson, G.A., Litchfield, K., Conde, L., Guerra-Assunção, J.A., Blighe, K., Biswas, D., Salgado, R., Lund, T., Al Bakir, M., Moore, D.A., Hiley, C.T., Loi, S., Sun, Y., Yuan, Y., AbdulJabbar, K., Turajilic, S., Herrero, J., Enver, T., Hadrup, S.R., Hackshaw, A., Peggs, K.S., McGranahan, N., Chain, B., TRACERx Consortium, Swanton, C. and Quezada, S.A.
The T cell differentiation landscape is shaped by tumour mutations in lung cancer.
Nature Cancer (2020)

López, S., Lim, E.L., Horswell, S., Haase, K., Huebner, A., Dietzen, M., Mourikis, T.P., Watkins, T.B.K., Rowan, A., Dewhurst, S.M., Birkbak, N.J., Wilson, G.A., Van Loo, P., Jamal-Hanjani, M.; TRACERx Consortium, Swanton, C. and McGranahan, N.
Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution.
Nature Genetics (2020)

Biswas, D., Birkbak, N.J., Rosenthal, R., Hiley, C.T., Lim, E.L., Papp, K., Boeing, S., Krzystanek, M., Djureinovic, D., La Fleur, L., Greco, M., Döme, B., Fillinger, J., Brunnström, H., Wu, Y., Moore, D.A., Skrzypski, M., Abbosh, C., Litchfield, K., Al Bakir, M., Watkins, T.B.K., Veeriah, S., Wilson, G.A., Jamal-Hanjani, M., Moldvay, J., Botling, J., Chinnaiyan, A.M., Micke, P., Hackshaw, A., Bartek, J., Csabai, I., Szallasi, Z., Herrero, J., McGranahan, N., Swanton, C.; TRACERx Consortium.
A clonal expression biomarker associates with lung cancer mortality.
Nature Medicine (2020)

Chemi, F., Rothwell, D.G., McGranahan, N., Gulati, S., Abbosh, C., Pearce, S.P., Zhou, C., Wilson, G.A., Jamal-Hanjani, M., Birkbak, N., Pierce, J., Kim, C.S., Ferdous, S., Burt, D.J., Slane-Tan, D., Gomes, F., Moore, D., Shah, R., Al Bakir, M., Hiley, C., Veeriah, S., Summers, Y., Crosbie, P., Ward, S., Mesquita, B., Dynowski, M., Biswas, D., Tugwood, J., Blackhall, F., Miller, C., Hackshaw, A., Brady, G., Swanton, C., Dive, C.; TRACERx Consortium.
Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse.
Nature Medicine (2020)

Joshi, K., de Massy, M.R., Ismail, M., Reading, J.L., Uddin, I., Woolston, A., Hatipoglu, E., Oakes, T., Rosenthal, R., Peacock, T., Ronel, T., Noursadeghi, M., Turati, V., Furness, A.J.S., Georgiou, A., Wong, Y.N.S., Ben Aissa, A., Sunderland, M.W., Jamal-Hanjani, M., Veeriah, S., Birkbak, N.J., Wilson, G.A., Hiley, C.T., Ghorani, E., Guerra-Assunção, J.A., Herrero, J., Enver, T., Hadrup, S.R., Hackshaw, A., Peggs, K.S., McGranahan, N., Swanton, C.; TRACERx Consortium, Quezada, S.A., Chain, B.
Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer.
Nature Medicine (2019)

Rosenthal, R., Cadieux, E.L., Salgado, R., Bakir, M.A., Moore, D.A., Hiley, C.T., Lund, T., Tanic, M., Reading, J.L., Joshi, K., Henry, J.Y., Ghorani, E., Wilson, G.A., Birkbak, N.J., Jamal-Hanjani, M., Veeriah, S., Szallasi, Z., Loi, S., Hellmann, M.D., Feber, A., Chain, B., Herrero, J., Quezada, S.A., Demeulemeester, J., Van Loo, P., Beck, S., McGranahan, N., Swanton, C.; TRACERx Consortium.
Neoantigen-directed immune escape in lung cancer evolution.
Nature (2019)

Arce Vargas, F., Furness, A.J.S., Litchfield, K., Joshi, K., Rosenthal, R., Ghorani, E., Solomon, I., Lesko, M.H., Ruef, N., Roddie, C., Henry, J.Y., Spain, L., Ben Aissa, A., Georgiou, A., Wong, Y.N.S., Smith, M., Strauss, D., Hayes, A., Nicol, D., O'Brien, T., Mårtensson, L., Ljungars, A., Teige, I., Frendéus, B.; TRACERx Melanoma Consortium; TRACERx Renal Consortium; TRACERx Lung Consortium, Pule, M., Marafioti, T., Gore, M., Larkin, J., Turajlic, S., Swanton, C., Peggs, K.S., Quezada, S.A.
Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies.
Cancer Cell (2018)

McGranahan, N., Rosenthal, R., Hiley, C.T., Rowan, A.J., Watkins, T.B.K., Wilson, G.A., Birkbak, N.J., Veeriah, S., Van Loo, P., Herrero, J., Swanton, C.; TRACERx Consortium.
Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution.
Cell (2017)

Jamal-Hanjani, M., Wilson, G., McGranahan, N., Birkbak, N., Watkins, T., Veeriah, S., Shafi, S., Johnson, D., Mitter, R., Salm, M., et al. on behalf of the TRACERx Consortium.
TRACERx – Tracking Non-Small Cell Lung Cancer Evolution.
The New England Journal of Medicine (2017)

Abbosh, C., Birkbak, N.J., Wilson, G.A., Jamal-Hanjani, M., Constantin, T., Salari, R., Le Quesne, J., Moore, D.A., Veeriah, S., Rosenthal, R., et al. on behalf of the TRACERx Consortium.
Phylogenetic ctDNA analysis depicts early stage lung cancer evolution.
Nature (2017)

Vargas, F.A., Furness, A.J.S., Solomon, I., Joshi, K., Mekkaoui, L., Lesko, M.H., Rota, E.M., Dahan, R., Georgiou, A., Sledzinska, A., et al. in collaboration with the TRACERx Consortium.
Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors.
Immunity (2017)

Hynds, R.E., Zacharias, W.J., Nikolić, M.Z., Königshoff, M., Eickelberg, O., Gosens, R., De Coppi, P., Janes, S.M., Morrisey, E., Clevers, H., Ryan, A.L., Stripp, B.R., Sun, X., Kim, C.F. and Lin, Q.S.
NHLBI and BREATH Consortium Workshop Report: Moving Forward in Lung Regeneration.
American Journal of Cell and Molecular Biology (2021)

Hynds, R.E., Vladimirou, E. and Janes, S.M.
The Secret Lives of Cancer Cell Lines.
Disease Models and Mechanisms (2018)

Hynds, R.E. and Janes, S.M.
Airway Basal Cell Heterogeneity and Lung Squamous Cell Carcinoma.
Cancer Prevention Research (2017)

Orr, J.C., Pearce, D.R. and Hynds, R.E.
Postnatal Lung Epithelial Stem Cells.
In 'Encyclopedia of Respiratory Medicine, 2nd Edition' (2021)

Lazarus, K.A., Pennycuick, A., Hynds, R.E. and Janes, S.M.
Lung Stem Cells and Cancer.
In 'ERS Monograph: Lung Stem Cells' (2021)

Hynds, R.E. and Giangreco, A.
Stem Cells of the Distal Bronchiolar Airways.
In ‘Stem Cells in the Lung’, p. 113-126 (2015)

Hamilton, N.J., Hynds, R.E., Butler, C.R., Giangreco, A. and Janes, S.M.
Lung Regeneration: The Developmental Biology Approach.
In ‘Regenerative Medicine Appications in Organ Transplantation’, p. 707-718 (2013)